Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model

The aim of this work was to develop a new in vitro lipolysis-permeation model predict the vivo absorption fenofibrate self-nanoemulsifying drug delivery systems (SNEDDSs). More specifically, intestinal lipolysis combined with mucus-PVPA (Phospholipid Vesicle-based Permeation Assay) permeability model. Biosimilar mucus (BM) added surface PVPA barriers closer simulate mucosa. SNEDDSs for which pharmacokinetic data after oral dosing rats available literature were prepared, and ability maintain solubilized during determined, followed by assessment permeation across barriers. amount over time did not correlate AUC (area under curve) plasma concentration curve. However, permeated displayed good correlation (R2 > 0.9). Thus, it concluded that lipolysis–mucus-PVPA model, simulating physiological digestion processes, able data, exhibiting great potential further prediction performance SNEDDSs.